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- mTOR Inhibition: Rapamycin inhibits the mechanistic Target of Rapamycin (mTOR), a protein pathway that senses nutrients and drives cell growth.
- Geroconversion Suppression: It slows the conversion of resting cells into senescent (aged) cells, a process called “geroconversion”
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- Autophagy Promotion: By reducing mTOR activity, it triggers autophagy—a cellular cleanup process that removes damaged components.
PubMed Central (PMC) (.gov) +4
- Lifespan Extension: Consistently shown to extend lifespan in yeast, worms, flies, and mice, even when started in old age.
- Reversal of Aging Markers: Studies in mice show it can reverse some aging declines, including improved heart and cognitive function.
- Skin Improvement: Topical rapamycin has been shown to reduce signs of skin aging, such as wrinkling and dermal atrophy, by reducing markers of cellular senescence.
PubMed Central (PMC) (.gov) +4
Tags:Rapamycin





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